CMC Analytical Development Scientist


Analytical Development Scientist – J33570

Role Type: Permanent

Salary: Dependent on Experience

My client based in the Cambridge area works within antibody based therapeutics and is currently seeking a scientist to join the CMC group.

With a background in protein or antibody you will be working to improve molecules quality and transform discovered leads into potential therapeutics.

Part of the role will be looking at early developability assessment studies to identify undesirable instabilities on a large panel of therapeutic antibody candidates.

The main responsibilities of this role will be:

* Develop analytical techniques for protein characterisation and identification for therapeutic application

* Be the expert on the MS system in-house for the team and the organisation

* Performing screening of proteins to assess chemical instabilities (e.g de-amidation, oxidation etc.)

* Product quality analysis including degradation mechanism or protein-protein interaction

* Conduct study of protein architecture, dynamics and interactions

* Collaborate with the research groups internally to support candidate molecules development

* Produce and maintain analytical development records, SOPs and regulatory documentation

* Contribution to cross-functional project teams including preparing and presenting updates, analytical expertise input.

To be considered for this role you will have the following experience:

* PhD (or equivalent) in a relevant biological subject (E)

* Strong experience in MS essential; ideally SYNAPT G2 (E)

* Industry expertise in bio-therapeutics analytical development (D)

* Technical expertise in protein characterisation through chromatography, electrophoresis, (E)

* Biophysical and mass spectrometry (E)

* Ability to produce reports and effectively share with stakeholders (E)

* Industry expertise in bio-therapeutics analytical development (D)

This is an excellent opportunity to join a successful company with strategic collaboration with existing manufacturer and EU patent on some of their molecules.

They are based on a science research park on the outskirt of Cambridge offering a short commute from the city of Cambridge by car, bike or shuttle bus. The campus has a cafeteria on site and a large park accessible to all employees.

If this role is of interest please apply online or for more information contact Lynda Dupont on 01223 607855 or [email protected]