050533 Scientific Officer in Cancer Genetics and Evolution


Scientific Officer in Cancer Genetics and Evolution
Centre for Cancer Research
£28,331- £32,816 p.a.

A graduate scientist is required to join the research group led by Ian Tomlinson, recently-appointed Director of the Edinburgh Cancer Research Centre. The group works on human cancer predisposition, functional analysis of cancer genes (including animal models), and cancer evolution. It is involved in both large data-driven projects, such as genome-wide association studies and the 100,000 genomes project, and in focussed analyses of genes and pathways that drive or predispose to human tumours, especially colorectal cancer.

The successful applicant will work on a project to analyse the role of isocitrate dehydrogenase (IDH1, IDH2) mutations in cancers. The frequencies and spectra of these mutations vary across the four main types of neoplasia in which they occur (glioma, AML, chondrosarcoma, cholangiocarcinoma), and it is likely that the explanation is that different tissue types require different levels of mutant IDH activity. The project team, including the successful applicant, will test this hypothesis in humans, cells and mouse models. There are potential implications for new therapeutic strategies against these hard-to-treat malignancies.

The successful candidate will also work closely with local colleagues and collaborators in Oxford and Birmingham.

The post is available on a fixed term basis with a working pattern of 35 hours per week from 1st January 2020, or as soon as possible thereafter. It is initially for 36 months, with the possibility of extension subject to available funding.

Please explore the role of IDH mutations in tumorigenesis and the group’s work by searching Pubmed, and address any queries to Ian Tomlinson ([email protected]).

Reference: 050533
Closing Date: 12 December 2019
For further particulars and to submit an application, visit the University of Edinburgh’s website via the apply button below.